Differences in response of myosin isozyme transition of ordinary and specialized myocardium to overload.
Why the study?
Does cardiac overload induce myosin isozyme transition in specialized myocardium (sinus node cells) compared to working myocardium in a canine model?
Population
Canine model of right atrial overload (n=4)
Comparison
Cardiac overload induced by artificial tricuspid… vs Normal right atria
Design
Preclinical
Follow-up
2 months
Authors
Discussion
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Member takes
Implication
Sinus node myosin isozymes may resist overload-induced shifts; hypothesis-generating for differential regulation in specialized myocardium.
Structured PICO
Does cardiac overload induce myosin isozyme transition in specialized myocardium (sinus node cells) compared to working myocardium in a canine model?
P
Population
Canine model of right atrial overload (n=4)
I
Intervention
Cardiac overload induced by artificial tricuspid valve regurgitation and pulmonary stenosis
C
Comparator
Normal right atria
O
Outcome
Distribution of myosin isozymes (alpha-HC and beta-HC) in sinus node cells and working myocardiumsurrogate
Myosin heavy chain isozymes in specialized myocardium (sinus node) appear protected from overload-induced transition seen in working myocardium.
Cite This Study
Nomoto et al. (1988) studied this question.