Isolation and characterization of two isozymes of myosin heavy chain from canine atrium.
Population
Canine heart tissue (atrium and ventricle)
Comparison
Fractionation and characterization of atrial… vs Ventricular myosin heavy chain isoforms
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Atrial-ventricular myosin isoform similarities in dogs warrant human validation; leaves open isoform-specific therapeutic targeting.
Structured PICO
P
Population
Canine heart tissue (atrium and ventricle)
I
Intervention
Fractionation and characterization of atrial myosin heavy chain isoforms (A-HC alpha and A-HC beta)
C
Comparator
Ventricular myosin heavy chain isoforms (V-HC alpha and V-HC beta)
O
Outcome
Peptide composition, primary structure, and Ca2+-activated ATPase activitiessurrogate
The canine atrium contains two distinct myosin heavy chain isozymes, with A-HC beta being structurally and enzymatically similar to the predominant ventricular form, V-HC beta.
Cite This Study
Komuro et al. (1986) studied this question.