Key result
Ventricular myosin heavy chain alpha and atrial heavy chain are indistinguishable proteins, and the type of heavy chain expressed in the atria is unaffected by the rabbit's thyroid state.
This preclinical study demonstrates that ventricular myosin heavy chain alpha and atrial heavy chain are structurally indistinguishable and their expression in the atria is not altered by thyroid status.
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Rabbit myosin data warrant no change in clinical thyroid-cardiac management; leaves open human translational relevance.
Chizzonite et al. (1984) studied Hyperthyroid, hypothyroid, and euthyroid state. Thyroid state (hyperthyroid, hypothyroid) vs. Euthyroid state was evaluated on Structural similarities of myosin heavy chains isolated from atria and ventricles. Ventricular myosin heavy chain alpha and atrial heavy chain are indistinguishable proteins, and the type of heavy chain expressed in the atria is unaffected by the rabbit's thyroid state.
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