Expression of rabbit ventricular alpha-myosin heavy chain messenger RNA sequences in atrial muscle.

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Population

Rabbit heart muscle

Comparison

Nuclease S1 mapping and cDNA cloning vs Ventricular beta, fast skeletal, and slow…

Design

Preclinical

Authors

Discussion

Alpha-HC likely encoded by one gene in rabbit atria and ventricles; leaves open chamber-specific myosin regulation in human disease.

Population

Rabbit heart muscle (ventricular and atrial muscle from hyperthyroid and hypothyroid rabbits, as well as fast and slow skeletal muscles)

Intervention

Nuclease S1 mapping and cDNA cloning (pMHC alpha 81)

Comparator

Ventricular beta, fast skeletal, and slow skeletal myosin heavy chain mRNAs

Outcome

Sequence homology and divergence of myosin heavy chain mRNAssurrogate

This basic science study demonstrates that rabbit atrial and ventricular alpha-myosin heavy chains are likely encoded by the same gene.

Sinha et al. (1984) studied this question.

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