Molecular cloning of mRNA sequences for cardiac alpha- and beta-form myosin heavy chains: expression in ventricles of normal, hypothyroid, and thyrotoxic rabbits.

Sinha et al. (1982) studied Thyrotoxic and hypothyroid states in rabbits. Thyrotoxic state and propylthiouracil-induced hypothyroidism vs. Normal state was evaluated on Expression of alpha and beta forms of myosin heavy chain transcripts. Thyrotoxic rabbit ventricles contained only pMHC alpha transcripts, whereas hypothyroid ventricles contained exclusively pMHC beta transcripts, correlating with myosin heavy chain protein forms.