Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.
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Key result
Molecular cloning of human cardiac alpha- and beta-form myosin heavy chain cDNAs revealed that MHC isozymic transition in pressure-overloaded atrium is regulated at a pretranslational level.
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Implication
Offers no immediate clinical guidance; leaves open identification of upstream transcriptional regulators in human atrial remodeling.
PICO
P
Population
Pressure overload in human atrium
O
Primary Outcome
MHC isozymic transition and mRNA expression
Cite This Study
Kurabayashi et al. (1988) studied Pressure overload in human atrium. Molecular cloning of human cardiac alpha- and beta-form myosin heavy chain cDNAs revealed that MHC isozymic transition in pressure-overloaded atrium is regulated at a pretranslational level.
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