Population
Human cardiac alpha-myosin heavy chain (alpha-MHC) cloned cDNA, genomic DNA, and PCR amplification products
Comparison
Nucleotide sequencing and amino acid sequence… vs Human cardiac beta-MHC, rat cardiac alpha- and…
Design
Preclinical
Authors
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Species-specific alpha-MHC differences limit rodent model translation; leaves open functional consequences of the missing divergent region in humans.
The complete sequencing of the human cardiac alpha-myosin heavy chain reveals structural and functional differences from other myosins, suggesting evolutionary changes toward the properties of cardiac beta-MHC.
Matsuoka et al. (1991) studied this question.
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