What question did this study set out to answer?

To characterize and map the anatomical distribution of fiber types and myosin heavy chain isoforms across human atrial and ventricular myocardium.

December 1, 1984Circulation ResearchOpen Access

Fiber types and myosin types in human atrial and ventricular myocardium. An anatomical description.

View Full Paper

Ask AI

Bookmark

Authors

No immediate clinical implications; leaves open functional roles of regional myosin heterogeneity in human cardiac chambers.

To characterize and map the anatomical distribution of fiber types and myosin heavy chain isoforms across human atrial and ventricular myocardium.
Generated 15 monoclonal antibodies against cardiac myosin from an obstructive cardiomyopathy patient and tested cross-reactivity against rodent myosin controls and chymotryptic fragments.
Evaluated atrial and ventricular tissue sections and whole hearts from two deceased young males using indirect immunofluorescence and adenosine triphosphatase staining.
Atrial tissue demonstrated at least two distinct myosin forms that showed direct correspondence between immunological reactivity and histochemical adenosine triphosphatase responses.
Ventricular tissue exhibited at least three distinct myosin types: one rare alkaline-stable V1-type myosin and two immunologically different alkaline-labile V3-type myosins.
Whole-heart mapping revealed chamber-specific regional myosin distributions containing small, non-randomly scattered zones of fiber variation.

Bouvagnet et al. (1984) studied this question.

View Full Paper

Ask AI

Bookmark