Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis.

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Population

Mononuclear cells isolated from synovial fluid of 29 patients with rheumatoid arthritis.

Comparison

In vitro stimulation with human 60-kD heat-shock… vs In vitro stimulation with bacterial hsp60

Design

Preclinical

Authors

Discussion

May support regulatory T-cell responses in RA; hypothesis-generating and requires clinical validation.

Population

Mononuclear cells isolated from synovial fluid of 29 patients with rheumatoid arthritis (mean age 52.3, 19 females, 10 males).

Intervention

In vitro stimulation with human 60-kD heat-shock protein (hsp60)

Comparator

In vitro stimulation with bacterial (Mycobacterium bovis) hsp60

Outcome

T cell proliferation and cytokine production (IFN-gamma and IL-4)surrogate

Human hsp60 stimulates regulatory T cell activity in rheumatoid arthritis synovial fluid, suggesting a potential mechanism for suppressing arthritis.

Roon et al. (1997) studied this question.

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