Key result
Among 100 children with NAFLD, type 2 NASH was the most common pattern (51% vs 17% for type 1) and was significantly associated with male sex (P<0.01) and non-white ethnicity (P<0.001).
Population
100 children and adolescents ages 2 to 18 years with biopsy-proven nonalcoholic fatty liver disease…
Design
Cohort
Authors
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Type 2 NASH predominance in boys and non-white children with NAFLD is hypothesis-generating; prospective studies needed before clinical adoption.
Observational (n=100)
Pediatric NAFLD presents with two distinct histological subtypes of NASH, with Type 2 being the most common pattern and varying significantly by sex and ethnicity.
Schwimmer et al. (2005) conducted an observational in Nonalcoholic fatty liver disease (NAFLD) (n=100). Biopsy-proven NAFLD was evaluated on Prevalence of NASH subtypes (Type 1 vs Type 2) and association with demographics. Among 100 children with NAFLD, type 2 NASH was the most common pattern (51% vs 17% for type 1) and was significantly associated with male sex (P<0.01) and non-white ethnicity (P<0.001).
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