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March 1, 1997Journal of VirologyOpen Access

Mapping and characterization of the origin of DNA replication of porcine circovirus

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Population

Porcine circovirus (PCV) DNA replication model

Comparison

Mutation of the nonanucleotide element (TAGTATTAC) vs Wild-type PCV

Design

Preclinical

Authors

AMAnnette MankertzRobert Koch InstituteFPF PerssonRobert Koch InstituteJMJoachim MankertzFederal Office of Consumer Protection and Food Safety

Discussion

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Overview

Characterizes the replication origin in porcine circovirus; leaves open its utility as an antiviral target in swine.

Structured PICO

P
Population
Porcine circovirus (PCV) DNA replication model
I
Intervention
Mutation of the nonanucleotide element (TAGTATTAC)
C
Comparator
Wild-type PCV
O
Outcome
DNA replicationsurrogate

The origin of DNA replication in porcine circovirus is located in a 111-bp fragment containing a critical nonanucleotide element.

Cite This Study

Mankertz et al. (1997) studied this question.

synapsesocial.com/papers/6a71bead8031ec7bb1dd1878https://doi.org/10.1128/jvi.71.3.2562-2566.1997
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Also Consider

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  1. 1Sequence-specific interaction with the viral AL1 protein identifies a geminivirus DNA replication origin.1992 · 143 citations
  2. 2In vitro cleavage and joining at the viral origin of replication by the replication initiator protein of tomato yellow leaf curl virus.1995 · 318 citations
  3. 3Geminiviruses: Genome structure and gene function1992 · 364 citations
  4. 4Nucleotide sequences at the phi X gene A protein cleavage site in replicative form I DNAs of bacteriophages U3, G14, and alpha 31982 · 47 citations