Key result
5-fluorouracil induced myocardial mitochondrial damage and excessive autophagy, with the degree of injury being more severe in aging rats and aggravated by prolonged administration.
Why the study?
5-fluorouracil can cause severe cardiac effects such as cardiomyopathy, angina, heart failure, and cardiogenic shock, but the specific pathologies and underlying mechanisms remain incompletely understood.
Does 5-fluorouracil induce myocardial injury and mitochondrial autophagy in aging rats?
Population
Sprague-Dawley rats aged 2 and 18 months
Comparison
5-fluorouracil administration vs saline control
Design
Animal experimental study
Follow-up
2 weeks
Authors
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Suggests monitoring for cardiotoxicity with prolonged 5-FU in older patients; leaves open mechanistic role of mitochondrial autophagy in humans.
Does 5-fluorouracil induce myocardial injury and mitochondrial autophagy in aging rats?
5-fluorouracil induces myocardial mitochondrial damage and excessive autophagy, which is more severe in aging rats, highlighting the increased risk of cardiotoxicity in the elderly.
Li et al. (2021) studied 5-fluorouracil-induced myocardial injury (n=60). 5-fluorouracil vs. Saline was evaluated on Myocardial mitochondrial damage and autophagy. 5-fluorouracil induced myocardial mitochondrial damage and excessive autophagy, with the degree of injury being more severe in aging rats and aggravated by prolonged administration.
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