Key result
Aminophylline administration during and after cardiac surgery improved GFR and creatinine levels compared to normal saline (p < 0.05) and reduced the need for inotropic drugs (P < 0.0001).
Why the study?
Does aminophylline reduce the incidence of acute kidney injury in patients undergoing major cardiovascular surgeries?
Population
Patients undergoing major cardiovascular surgeries
Comparison
Aminophylline vs Normal saline (similar volume)
Design
Other
Follow-up
3 days postsurgery
Authors
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Aminophylline may improve renal function and reduce inotropes after cardiac surgery; hypothesis-generating and requires randomized confirmation.
RCT
Does aminophylline reduce the incidence of acute kidney injury in patients undergoing major cardiovascular surgeries?
p-value: p=< 0.05
Aminophylline administration during and after cardiac surgery may preserve renal function, reduce the incidence of acute kidney injury, and decrease the need for inotropic support.
Shahbazi et al. (2017) conducted an RCT in Cardiac surgery. Aminophylline vs. Normal saline was evaluated on Acute kidney injury (RIFLE criteria) and renal function (GFR, Cr) (p=< 0.05). Aminophylline administration during and after cardiac surgery improved GFR and creatinine levels compared to normal saline (p < 0.05) and reduced the need for inotropic drugs (P < 0.0001).
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