Key result
Type 1 diabetes was not associated with a significant overall difference in pancreatic shear wave velocity compared to healthy volunteers (1.1 vs 1.0 m/s, p=0.2453), although stiffness was higher in the tail segment.
Why the study?
The study was conducted to establish pancreatic shear wave elastography by comparing measurements in patients with type 1 diabetes and healthy controls, evaluating its potential for screening or prevention.
Does ultrasound point shear wave elastography detect differences in pancreatic tissue stiffness between patients with type 1 diabetes and healthy volunteers?
Case-Control (n=30)
None
No
Does ultrasound point shear wave elastography detect differences in pancreatic tissue stiffness between patients with type 1 diabetes and healthy volunteers?
Absolute Event Rate: 1.1% vs 1%
p-value: p=0.2453
Ultrasound point shear wave elastography revealed no overall difference in pancreatic stiffness between type 1 diabetes patients and healthy volunteers, though higher stiffness was noted in the tail segment of diabetic patients.
Pancreatic SWE shows no overall T1D difference; leaves open tail stiffness as a hypothesis-generating regional marker for validation.
BACKGROUND: The aims of this study were to establish shear wave elastography of the pancreas by comparing measurements in patients with type 1 diabetes (T1D) and healthy volunteers and to consider whether this method could contribute to the screening or prevention of T1D. METHODS: This pilot study included 15 patients with T1D (10 men, 5 women) and 15 healthy volunteers (10 men, 5 women) as controls. Measurements were performed with a Siemens Acuson S3000 (Siemens Healthcare, Erlangen, Germany) using a 6C1 convex transducer and the Virtual Touch™ tissue quantification (VTQ) method. RESULTS: The mean shear wave velocity of the head of the pancreas was 1.0 ± 0.2 m/s (median: 1.1 m/s) for the study group and likewise 1.0 ± 0.2 m/s (median: 0.9 m/s) for the control group. Velocities of 1.2 ± 0.2 m/s (median: 1.2 m/s) were measured in the body of the pancreas in both groups. There was a significant difference between the values obtained in the tail of the pancreas: patients 1.1 ± 0.1 m/s (median: 1.0 m/s) versus controls 0.9 ± 0.1 m/s (median: 0.8 m/s) (p = 0.0474). The mean value in the whole pancreas of the study group was not significantly above that of the control group: 1.1 ± 0.1 m/s (median: 1.0 m/s) versus 1.0 ± 0.1 m/s (median: 1.0 m/s) (p = 0.2453). CONCLUSIONS: Sonoelastography of the pancreas revealed no overall difference between patients with T1D and healthy volunteers. Patients with T1D showed higher values only in the tail segment. Future studies need to determine whether specific regional differences can be found in a larger study population.
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Püttmann et al. (2018) conducted a case-control in Type 1 diabetes (n=30). Type 1 diabetes vs. Healthy volunteers was evaluated on Mean shear wave velocity of the whole pancreas (p=0.2453). Type 1 diabetes was not associated with a significant overall difference in pancreatic shear wave velocity compared to healthy volunteers (1.1 vs 1.0 m/s, p=0.2453), although stiffness was higher in the tail segment.
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