What question did this study set out to answer?

Elucidate the atomistic mechanisms of uric acid recognition and translocation mediated by human urate anion transporter 1 (URAT1).

December 17, 2020ACS OmegaOpen Access

Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

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Elucidate the atomistic mechanisms of uric acid recognition and translocation mediated by human urate anion transporter 1 (URAT1).
Atomistic structural characterization of human urate anion transporter 1 (URAT1).
Analysis of specific amino acid residues and transmembrane domains involved in substrate binding and transport.
Segments W357-F365 within transmembrane domain 7 (TMD7) and P484-R487 within TMD11 are critical for uric acid recognition and translocation.
Specific amino acid residues F241, H245, and R477 play essential roles in mediating URAT1 substrate interaction and transport activity.

Implication

Structural analysis reveals critical transmembrane residues governing uric acid translocation in human URAT1, highlighting target sites for transport inhibition.

Abstract

: W357-F365 in TMD7, P484-R487 in TMD11, and residues F241, H245, and R477 were found to be critical for the translocation and recognition of uric acid.

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Cite This Study

Zhao et al. (2020) studied this question.

synapsesocial.com/papers/6a71c540660549caf2c642a3 https://doi.org/10.1021/acsomega.0c05360

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Implication

Structural analysis reveals critical transmembrane residues governing uric acid translocation in human URAT1, highlighting target sites for transport inhibition.

Abstract

: W357-F365 in TMD7, P484-R487 in TMD11, and residues F241, H245, and R477 were found to be critical for the translocation and recognition of uric acid.

Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

Key Points

Implication

Abstract

Discussion

Cite This Study

Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

Key Points

Implication

Abstract

Discussion

Cite This Study

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