Key result
In patients with idiopathic inflammatory myopathies, myocarditis was strongly indicated by elevated NT-proBNP (AUC 0.973) and cTnI (AUC 0.915), along with diffuse late gadolinium enhancement.
Why the study?
Myocarditis is a rare complication of idiopathic inflammatory myopathies that is usually underestimated due to limited clinical use of endomyocardial biopsy and cardiovascular magnetic resonance.
Population
62 patients with initial untreated idiopathic inflammatory myopathies
Comparison
Myocarditis vs without cardiac involvement
Design
Case-control study
Authors
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May aid myocarditis detection in IIM; leaves open prospective validation before clinical adoption.
Case-Control (n=62)
No
Effect estimate: AUC 0.973 for NT-proBNP
p-value: p=<0.05
Elevated cTnI, NT-proBNP, positive AMA-M2 antibody, and specific CMR late gadolinium-enhancement patterns are key identifiers of overt myocarditis in patients with idiopathic inflammatory myopathies.
Liu et al. (2020) conducted a case-control in Idiopathic inflammatory myopathies (IIMs) (n=62). Myocarditis vs. No cardiac involvement was evaluated on Area under the curve for indicating myocarditis (AUC 0.973 for NT-proBNP, p=<0.05). In patients with idiopathic inflammatory myopathies, myocarditis was strongly indicated by elevated NT-proBNP (AUC 0.973) and cTnI (AUC 0.915), along with diffuse late gadolinium enhancement.
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