Key points are not available for this paper at this time.
Design
Review
Answers are grounded in this paper and cite their sources.
This review summarizes the cellular mechanisms by which cAMP and cGMP mediate vascular smooth muscle relaxation and their role in the pathophysiology of chronic portal hypertension.
The role of cyclic nucleotides as modulators of vascular smooth muscle tone has been widely studied. Yet the cellular mechanisms whereby cAMP and cGMP promote vascular relaxation remain highly controversial. The purpose of this review is to summarize a large and expanding literature with particular emphasis on the cellular mechanisms of cAMP- and cGMP-induced relaxation of vascular smooth muscle. The review addresses the following topics: regulation of vascular tone, mechanisms of cAMP- and cGMP-mediated vascular smooth muscle relaxation, modulation of [Ca2+]i by cAMP and cGMP, effects of cAMP and cGMP on the Ca2+ sensitivity of the contractile apparatus, and pathophysiology of the resistance vasculature in chronic portal hypertension with particular emphasis on cAMP and cGMP dependent pathways.
No takes yet. Share an insight, caveat, or question.
Taylor et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: