Why the study?
Do cGMP and cAMP analogues alter intracellular calcium, myosin light chain phosphorylation, and contraction in human myometrium?
Population
Human myometrial smooth muscle cells in culture, human uterine smooth muscle strips, bovine tracheal smooth…
Comparison
Analogues of cAMP and cGMP, and activators of… vs Untreated baseline or endothelin-stimulated state
Design
Preclinical
Authors
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Should not alter tocolytic practice; hypothesis-generating for cyclic nucleotide signaling in human myometrium.
Do cGMP and cAMP analogues alter intracellular calcium, myosin light chain phosphorylation, and contraction in human myometrium?
While cGMP and cAMP decrease the force and frequency of spontaneous contractions in human myometrium, this tissue is less responsive to cyclic nucleotides compared to other smooth muscle types.
Word et al. (1991) studied this question.
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