Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy

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Population

Rat myometrium (from pregnant, nonpregnant cycling, and ovariectomized rats) and aortic smooth muscle

Comparison

cGMP, NO donor, estradiol, and progesterone vs Nonpregnant cycling rats, aortic smooth muscle…

Design

Preclinical

Authors

Discussion

Rat data implicate progesterone-PKG downregulation in myometrial cGMP insensitivity; leaves open relevance to human labor regulation.

Population

Rat myometrium (from pregnant, nonpregnant cycling, and ovariectomized rats) and aortic smooth muscle

Intervention

cGMP, NO donor (S-nitroso-N-acetylpenicillamine), estradiol, and progesterone

Comparator

Nonpregnant cycling rats, aortic smooth muscle, or untreated controls

Outcome

Relaxation of smooth muscle and levels of cGMP-dependent protein kinase (PKG) expressionsurrogate

In rats, pregnancy-induced insensitivity of myometrium to cGMP relaxation is mediated by progesterone-driven decreases in PKG expression.

Word et al. (1998) studied this question.

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