Key result
Local pregnancy factors increase DEA/NO inhibition of spontaneous uterine contractions by ~61% vs nonpregnant horns.
Why the study?
The association of local versus systemic pregnancy factors with iNOS mRNA expression and the inhibitory effects of cGMP-increasing agents on uterine contractile activity was unclear.
Population
Rats nonpregnant and pregnant on day 17 and 21 of gestation
Comparison
Pregnant uterine horns vs nonpregnant uterine horns
Design
Preclinical experimental study with RT-PCR and isometric contraction recordings
Authors
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May enhance NO donor effects in pregnant rat uterus; hypothesis-generating for human myometrial disorders, should not yet change practice.
Absolute Event Rate: 56.1% vs 34.9%
p-value: p=<0.01
Local pregnancy factors are required for signal transduction from NO to soluble guanylate cyclase during maximal iNOS mRNA expression in rat myometrium.
Okawa et al. (2004) studied Pregnancy (uterine contractility). Local pregnancy factors (pregnant uterine horn) vs. Nonpregnant uterine horn was evaluated on Maximal inhibition of spontaneous uterine contractions by DEA/NO (p=<0.01). Local pregnancy factors significantly increased the maximal inhibitory effect of the nitric oxide donor DEA/NO on spontaneous uterine contractions compared to nonpregnant horns (56.1% vs 34.9%, p<0.01).
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