Key result
Differential NOS activity during labor may drive connective tissue remodeling during cervical ripening.
Population
Rat cervix and uterus models
Design
Review
Authors
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Leaves open NOS as a labor target; requires prospective trials before any clinical consideration.
Nitric oxide synthase activity is differentially regulated in the uterus and cervix during labour, suggesting a role in connective tissue remodeling during cervical ripening.
Marinella Rosselli (1997) conducted a review in Pregnancy and labour. Nitric oxide synthase (NOS) expression was evaluated. Nitric oxide synthase activity in the uterus and cervix is differentially regulated during labour and may be involved in connective tissue remodelling during cervical ripening.
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