Key result
Nitric oxide and cGMP biosynthesis increases during pregnancy, though the relative contribution of maternal vasculature and other tissues to reduced vascular tone requires further investigation.
NO and cGMP biosynthesis increases during pregnancy, likely contributing to circulatory changes, though further research is needed to clarify its role in maternal vascular tone.
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Supports gestational NO/cGMP rise without changing practice; leaves open vascular versus tissue contributions.
McLaughlin et al. (1995) conducted a review in Pregnancy. Nitric oxide biosynthesis was evaluated. Nitric oxide and cGMP biosynthesis increases during pregnancy, though the relative contribution of maternal vasculature and other tissues to reduced vascular tone requires further investigation.
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