Why the study?
Does pregnancy alter renal nitric oxide synthase isoform expression and NO production in rats?
Population
Female rats (prepregnant, pregnant at days 6, 13, and 19 of gestation, and at day 4 postpartum)
Comparison
Pregnancy (gestational stages) vs Prepregnant (virgin) state
Design
Preclinical
Follow-up
Up to day 4 postpartum
Authors
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Rat data implicate iNOS/nNOS in gestational renal NO increases; leaves open translation to human pregnancy hemodynamics.
Does pregnancy alter renal nitric oxide synthase isoform expression and NO production in rats?
Increased NO production and renal hemodynamics during pregnancy in rats may be driven by the upregulation of iNOS and nNOS in the kidney, rather than eNOS.
Alexander et al. (1999) studied this question.
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