Population
Normal conscious, chronically instrumented virgin (n=6) and pregnant rats (n=9) at day 16 of gestation
Comparison
Infusion of nNOS inhibitor 7-nitroindazole (7-NI) vs Virgin rats receiving the same infusion, and…
Design
Preclinical
Authors
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nNOS may mediate gestational renal hyperfiltration in rats; leaves open relevance to human pregnancy and requires clinical validation.
Inhibition of nNOS decreases renal plasma flow and glomerular filtration rate in pregnant rats, suggesting nNOS mediates pregnancy-induced renal hemodynamic changes.
Abram et al. (2001) studied this question.
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