Population
Pregnant rats on day 20 of gestation and age-matched nonpregnant rats
Comparison
Pregnancy (gestation) vs Age-matched nonpregnant rats
Design
Preclinical
Follow-up
Day 20 of gestation
Authors
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Hypothesis-generating for AVP-NOS roles in gestational vasodilation; leaves open human translation and does not alter practice.
Pregnancy upregulates constitutive NOS isoforms in rats, which may mediate the peripheral arterial vasodilation and hyposmolality characteristic of gestation.
Xu et al. (1996) studied this question.
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