December 1, 1994Endocrinology

Pregnancy increases guanosine 3',5'-monophosphate in the myometrium independent of nitric oxide synthesis.

View Full Paper

Ask AI

Bookmark

Population

Pregnant and nonpregnant guinea pigs

Comparison

Pregnancy, L-nitro-arginine methyl ester, and… vs Nonpregnant control animals

Design

Preclinical

Authors

CWCarl P. WeinerUniversity of Kansas Medical Center RKRichard G. KnowlesStevenage Bioscience Catalyst SNSteven E. NelsonWalt Disney (United States)

Discussion

Member takes

Implication

Suggests cGMP may mediate myometrial quiescence independently of NOS; hypothesis-generating with no immediate clinical implications.

Structured PICO

Population

Pregnant and nonpregnant guinea pigs

Intervention

Pregnancy (gestational age), L-nitro-arginine methyl ester (200 mg/kg), and Estradiol (500 micrograms/kg for 5 days)

Comparator

Nonpregnant control animals

Outcome

Myometrial cGMP content and NO synthase (NOS) activitysurrogate

Pregnancy dramatically increases myometrial cGMP by a mechanism independent of nitric oxide synthesis, suggesting cGMP mediates myometrial quiescence.

Cite This Study

Weiner et al. (1994) studied this question.

synapsesocial.com/papers/6a8be68ac716e89f35df029a https://doi.org/10.1210/endo.135.6.7988434

View Full Paper

Ask AI

Bookmark

Pregnancy increases guanosine 3',5'-monophosphate in the myometrium independent of nitric oxide synthesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pregnancy increases guanosine 3',5'-monophosphate in the myometrium independent of nitric oxide synthesis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider