October 1, 1990British Journal of Haematology
Differential effects of recombinant human colony stimulating factor (rh G‐CSF) on stem cells in marrow, spleen and peripheral blood in mice
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Discussion
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Implication
Randomized trial evaluates G-CSF effects on stem cells in mice, suggesting significant shifts in progenitor levels.
Key Points
- This research aims to examine how recombinant human G-CSF affects stem cell and progenitor numbers in mice.
- C57BL mice received subcutaneous injections of 3.75 micrograms rh G-CSF per mouse per day for 6 days.
- Parameters measured included CFU-S, CFU-E, and CFU-GM in marrow, spleen, and peripheral blood.
- Marrow CFU-S increased to 160% on day 2 but dropped to 50% of control by day 6.
- Splenic and peripheral blood CFU-S increased by 20-fold and 10-fold, respectively.
- Marrow CFU-E dropped to 40% of control, while splenic CFU-E increased 10-fold.
Cite This Study
Bungart et al. (1990) studied this question.