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January 21, 2003BioinformaticsOpen Access

Efficient selective screening of haplotype tag SNPs

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Authors

XKXiayi KeTibet UniversityLCLon R. CardonBroad Institute

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Implication

Bioinformatic tool development demonstrates automated selection of minimal haplotype tagging SNPs across genomic datasets, facilitating streamlined disease gene mapping.

Key Points

  • Develop an efficient, flexible computational tool to identify minimal sets of haplotype tagging SNPs for large-scale genetic mapping studies.
  • Engineered SNPtagger, a Java-based software tool designed to screen for minimal marker subsets that capture comprehensive haplotype information.
  • Implemented customizable options enabling marker inclusion, marker exclusion, and generation of alternative selection panels.
  • Successfully automated the identification of minimal haplotype tagging SNP sets from high-density genomic datasets.
  • Provided multiple functional marker configurations to accommodate user-defined experimental constraints in trait mapping.

Cite This Study

Ke et al. (2003) studied this question.

synapsesocial.com/papers/6a71c729ac440176ef2a573fhttps://doi.org/10.1093/bioinformatics/19.2.287
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