Key result
Calcium-related microRNAs play a crucial role in regulating cardiac calcium signaling and represent a potential therapeutic target for heart diseases including heart failure and myocardial infarction.
Why the study?
Impaired Ca2+ handling proteins are central to heart disease, and the role of microRNAs in regulating cardiac Ca2+ cycling warrants synthesis to explore their therapeutic potential.
MicroRNAs play a crucial role in regulating cardiac calcium signaling and represent a promising therapeutic target for various heart diseases.
Hypothesis-generating for microRNA therapies in heart failure and MI; prospective trials needed before clinical adoption.
In hearts, calcium (Ca2+) signaling is a crucial regulatory mechanism of muscle contraction and electrical signals that determine heart rhythm and control cell growth. Ca2+ signals must be tightly controlled for a healthy heart, and the impairment of Ca2+ handling proteins is a key hallmark of heart disease. The discovery of microRNA (miRNAs) as a new class of gene regulators has greatly expanded our understanding of the controlling module of cardiac Ca2+ cycling. Furthermore, many studies have explored the involvement of miRNAs in heart diseases. In this review, we aim to summarize cardiac Ca2+ signaling and Ca2+-related miRNAs in pathological conditions, including cardiac hypertrophy, heart failure, myocardial infarction, and atrial fibrillation. We also discuss the therapeutic potential of Ca2+-related miRNAs as a new target for the treatment of heart diseases.
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Park et al. (2021) conducted a review in Heart disease (cardiac hypertrophy, heart failure, myocardial infarction, atrial fibrillation). Ca2+-related miRNAs was evaluated. Calcium-related microRNAs play a crucial role in regulating cardiac calcium signaling and represent a potential therapeutic target for heart diseases including heart failure and myocardial infarction.
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