Key result
Major depression in type 2 diabetes was associated with a significant positive correlation between right orbitofrontal region volumes and executive functioning.
Why the study?
Is there a relationship between prefrontal cortex volumes and executive functioning in adults with type 2 diabetes and major depression?
Cross-Sectional (n=66)
Is there a relationship between prefrontal cortex volumes and executive functioning in adults with type 2 diabetes and major depression?
Neurobiological changes in the right orbitofrontal region may contribute to cognitive dysfunction in adults with comorbid type 2 diabetes and major depression.
May link right orbitofrontal volume to executive function in comorbid diabetes and depression; hypothesis-generating and requires longitudinal validation before clinical relevance.
Depression is often comorbid with type 2 diabetes. Depression may increase vulnerability to and/or exacerbate existing cognitive deficits. Little is known about the brain pathophysiology underlying depression and cognitive abnormalities in diabetes. The aim of this study was to examine the relationship of orbitofrontal and anterior cingulate volumes with executive functioning and attention/processing speed in type 2 diabetic participants with and without major depression. A total of 21 diabetic participants with major depression, 23 diabetic participants with no depression, and 22 healthy controls were compared. Using brain magnetic resonance imaging, volumetric measures of the prefrontal cortex were examined in relation to executive functioning and attention/processing speed. Partial correlations suggested a significant positive relationship between right orbitofrontal regions and executive functioning in the group with diabetes and depression only, indicating that neurobiological changes in the orbitofrontal region may contribute to observed cognitive dysfunction.
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Watari et al. (2008) conducted a cross-sectional in Type 2 diabetes and major depression (n=66). Major depression vs. No depression (in type 2 diabetes) and healthy controls was evaluated on Relationship of orbitofrontal and anterior cingulate volumes with executive functioning and attention/processing speed. Major depression in type 2 diabetes was associated with a significant positive correlation between right orbitofrontal region volumes and executive functioning.
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