Key result
Methanol extract of Bauhinia variegata leaves reduced morbidity, mortality, virus titers, and pathological area in the heart tissues of CVB3-infected mice compared to infected controls.
Why the study?
Does Bauhinia variegata extract reduce Coxsackievirus B3 infection severity in preclinical models?
Does Bauhinia variegata extract reduce Coxsackievirus B3 infection severity in preclinical models?
Methanol extract of Bauhinia variegata leaves shows promising antiviral effects against Coxsackievirus B3 in preclinical models, potentially offering a future therapeutic avenue for viral myocarditis.
Coxsackievirus B3 (CVB3) is one of the most viral agents that cause myocarditis in human, particularly in infants and young children. However, up to date, there are no vaccine or antiviral agents to prevent and/or treat the disease caused by this virus. The aim of this study was to determine the antiviral activities of Bauhinia variegata extracts against CVB3 infection in vitro and in vivo. Five extracts from B. variegate leaves were tested for their antiviral activity against CVB3 in vitro by applying three different strategies using MTT and TCID50 assays. The antiviral activity in vivo was performed by monitoring of morbidity, mortality, the heart index, virus titers, and pathologic scores. In addition, measuring the activities of Aspartate Transaminase (AST), Creatine Kinase (CK), and Lactic Dehydrogenase (LDH) enzymes in infected mice with CVB3. Our results suggested that the methanol extract had the highest impact on viral infection in vitro as compared to others and it may work via blocking of the viral receptors. Moreover, this extract reduced the morbidity and mortality, the virus titers, and pathological area in the heart tissues of infected mice. Also, it maintained AST, CK and LDH enzymes at normal levels in the sera of the infected mice, when compared with infected control. In conclusion, the methanol extract of B. variegata leaves may play potential role in the treatment of CVB3 infection.
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Shaheen et al. (2017) studied Coxsackievirus B3 (CVB3) infection. Bauhinia variegata methanol extract vs. Infected control was evaluated on Antiviral activity (morbidity, mortality, heart index, virus titers, pathologic scores, AST, CK, LDH). Methanol extract of Bauhinia variegata leaves reduced morbidity, mortality, virus titers, and pathological area in the heart tissues of CVB3-infected mice compared to infected controls.
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