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June 1, 1983Journal of Biological ChemistryOpen Access

Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation.

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Population

multisubunit phosphatase purified from turkey gizzard smooth muscle

Comparison

calmodulin binding to myosin light chain kinase vs absence of bound calmodulin

Design

Preclinical

Authors

MPM D PatoLund UniversityRARobert AdelsteinHeart Failure / Cardiomyopathy

Discussion

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Implication

Calmodulin may selectively regulate MLCK dephosphorylation in smooth muscle; leaves open its role in cardiovascular contractility and requires in vivo validation.

Structured PICO

P
Population
multisubunit phosphatase purified from turkey gizzard smooth muscle
I
Intervention
calmodulin binding to myosin light chain kinase
C
Comparator
absence of bound calmodulin
O
Outcome
dephosphorylation of myosin light chain kinasesurrogate

Calmodulin binding to myosin light chain kinase protects one of its phosphorylation sites from dephosphorylation by a specific multisubunit phosphatase.

Cite This Study

Pato et al. (1983) studied this question.

synapsesocial.com/papers/6a71ca888031ec7bb1dd1cc3https://doi.org/10.1016/s0021-9258(18)32330-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification of Gizzard Myosin Light-Chain Phosphatase, and Reversible Changes in the ATPase and Superprecipitation Activities of Actomyosin in the Presence of Purified Preparations of Myosin Light-Chain Phosphatase and Kinase11982 · 35 citations
  2. 2Self-association of chicken gizzard filamin and heavy merofilamin1980 · 32 citations
  3. 3The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3‘:5‘ cAMP-dependent protein kinase.1981 · 392 citations
  4. 4Phosphorylation-Dephosphorylation of Enzymes1979 · 2,219 citations
  5. 5Comparison of the substrate specificities of protein phosphatases involved in the regulation of glycogen metabolism in rabbit skeletal muscle1977 · 193 citations