Chlorambucil Treatment of Patients With Cold Agglutinin Syndrome

Four patients aged 62 to 78 years with the cold agglutinin syndrome have been treated intermittently or continuously with chlorambucil for one to seven years. This resulted in a decreased susceptibility to the cold so that Raynaud phenomena and hemoglobinuria were avoided in the winter. The hemoglobin value increased, the concentration of IgM-globulin in serum was nearly normalized, and the cold agglutinin titre decreased by a factor 3-30. The thermal amplitude was lowered by 2.2-7.2°C.