January 1, 2001Annals of Neurology

Focal cooling rapidly terminates experimental neocortical seizures

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Why the study?

Does focal cooling reduce seizure duration in an experimental rat model of neocortical seizures?

Population

Anesthetized rats with neocortical seizures induced by 4-aminopyridine (4-AP) injection (n=10)

Comparison

Focal cooling of the exposed cortical surface to… vs Uncooled seizures and Peltier device placed…

Design

Preclinical

Authors

XYXiaofeng YangSoochow University SRSteven M. RothmanBarnes-Jewish Hospital

Discussion

Member takes

Implication

Does not alter clinical seizure management; leaves open translation of focal cooling from rat models to human epilepsy.

Structured PICO

Does focal cooling reduce seizure duration in an experimental rat model of neocortical seizures?

Population

Anesthetized rats with neocortical seizures induced by 4-aminopyridine (4-AP) injection (n=10)

Intervention

Focal cooling of the exposed cortical surface to 20-25 degrees C at seizure onset using a thermoelectric (Peltier) device

Comparator

Uncooled seizures (control) and Peltier device placed close to the cortical surface without physical contact

Outcome

Seizure durationsurrogate

Focal cooling with a Peltier device rapidly terminates experimental neocortical seizures in rats without causing acute neuronal injury.

Cite This Study

Yang et al. (2001) studied this question.

synapsesocial.com/papers/6a71cbcca7fbea1e44088291 https://doi.org/10.1002/ana.1021

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Focal cooling rapidly terminates experimental neocortical seizures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Focal cooling rapidly terminates experimental neocortical seizures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider