Prilling process applied to collagen solutions

The present work concerns the preparation of microbeads of collagen by a prilling process.Collagen is one of the main components of vertebrate proteins, especially in. such tissues as skin, tendons, placenta, … Furthermore, it has some properties which makes it interesting to use as a biomaterial: biocompatibility, biodegradability, high tensile strength, hemostatic power, participation to the wound healing.The patented process which is developped in this paper combines two techniques :• breaking of a capillary flow by prillingand• reticulation of collagen after oxydation with periodic acid.It uses neither organic solvents, nor variation of temperature and allows the production of microbeads which can be utilized for many different medical applications.