Key result
Platelet activation during myocardial ischemia releases substances such as serotonin, histamine, and ATP that possess potent pro-arrhythmic properties and contribute to sudden cardiac death.
Design
Review
Authors
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Extends platelet role in SCD beyond thrombosis; leaves open whether mediator-targeted therapies improve outcomes.
This review highlights that platelets contribute to sudden cardiac death not only through coronary occlusion but also by releasing pro-arrhythmic substances during ischemia.
Jong et al. (2010) conducted a review in Cardiac arrhythmia and sudden cardiac death. Platelet activation and products was evaluated. Platelet activation during myocardial ischemia releases substances such as serotonin, histamine, and ATP that possess potent pro-arrhythmic properties and contribute to sudden cardiac death.
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