Population
in vivo dog model of spontaneous occlusive coronary thrombus formation
Design
Preclinical
Follow-up
62 +/- 18 minutes after discontinuation of current
Authors
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No immediate clinical implications; hypothesis-generating for serotonin's role in coronary thrombus formation.
In a dog model, marked increases in coronary sinus serotonin levels prior to total vessel occlusion suggest platelet aggregation plays a significant role in occlusive coronary thrombus evolution.
Benedict et al. (1986) studied this question.
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