Key result
Oral clonidine (200 µg) significantly attenuated heart rate and blood pressure increases during laryngoscopy and intubation compared to oral gabapentin (800 mg), while both provided similar preoperative sedation.
Why the study?
Does oral clonidine reduce the laryngoscopic stress response (heart rate and blood pressure variation) compared to oral gabapentin in adult patients undergoing general anesthesia?
RCT (n=100)
Double-blind
computer-generated random number list
Does oral clonidine reduce the laryngoscopic stress response (heart rate and blood pressure variation) compared to oral gabapentin in adult patients undergoing general anesthesia?
Oral clonidine 200 µg is more efficacious than oral gabapentin 800 mg in attenuating the hemodynamic stress response to laryngoscopy and intubation, while providing comparable preoperative sedation.
Answers are grounded in this paper and cite their sources.
Supports preferring clonidine over gabapentin for intubation hemodynamics; extends head-to-head RCT data on premedication agents.
BACKGROUND: Laryngoscopy and endotracheal intubation (L and I) is associated with rise in blood pressure (BP), heart rate (HR), leading to adverse cardiological outcome especially in susceptible individuals. To compare the BP, HR during L and I as well as to evaluate the preoperative sedation status between oral clonidine (Group C) and oral gabapentine (Group G) as premedication for the patients undergoing major surgery under general anesthesia (GA). MATERIALS AND METHODS: From April 2008 to December 2009; in a prospective, double-blinded, and randomized controlled study; 100 adult patients of either sex, aged 20-45, of American Society of Anesthesiologists status I and II scheduled to undergo major surgery of >1 hour duration, randomly allocated into groups C and G were pre treated with oral clonidine (200 µg) and gabapentin (800 mg) respectively 2 h prior to induction. Preoperative sedation was assessed 2 h after premedication administration. Hemodynamic parameters were noted just before induction, during L and I 1,3,5,7, and10 min after intubation. The results obtained were then analyzed with statistical unpaired "t" test and Chi-square test and compared. RESULTS AND ANALYSIS: Preoperative sedation between two groups were similar but group C attenuated HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) more significantly before induction, during L and I, 1, 3, and 5 min, following L and I, while comparing with group G. Again gabapentin-reduced HR, BP, (SBP, DBP, MBP) significantly more at 7 and 10 min after L and I on comparison clonidine. CONCLUSION: Oral clonidine is equally effective in producing preoperative sedation in comparison to oral gabapentin, while on the contrary oral clonidine is more efficacious in reducing laryngoscopic stress response than oral gabapentin.
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Das et al. (2015) conducted an RCT in Patients undergoing major surgery under general anesthesia (n=100). Oral clonidine vs. Oral gabapentin (800 mg) was evaluated on Heart rate variation during laryngoscopy and intubation (p=<0.05). Oral clonidine (200 µg) significantly attenuated heart rate and blood pressure increases during laryngoscopy and intubation compared to oral gabapentin (800 mg), while both provided similar preoperative sedation.
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