Key result
Serum 25-hydroxyvitamin D level was independently associated with aortic distensibility (β = 0.369, p < 0.001) and left ventricle mass index (β = -0.259, p = 0.001) in newly diagnosed type 2 DM.
Why the study?
Is serum 25-hydroxyvitamin D level associated with aortic distensibility and left ventricle hypertrophy in patients with newly diagnosed type 2 diabetes mellitus?
Cross-Sectional (n=136)
Is serum 25-hydroxyvitamin D level associated with aortic distensibility and left ventricle hypertrophy in patients with newly diagnosed type 2 diabetes mellitus?
Effect estimate: β = 0.369 for aortic distensibility; β = -0.259 for LVMI
p-value: p=<0.001 for aortic distensibility; 0.001 for LVMI
In patients with newly diagnosed type 2 diabetes, lower serum vitamin D levels are associated with impaired aortic distensibility and increased left ventricular mass index.
We aimed to evaluate the association between serum vitamin D status and elastic properties of aorta in patients with diabetes mellitus (DM). We studied 136 patients with newly diagnosed DM (mean age: 62.9 ± 10.6 years). Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Left ventricle mass index (LVMI) was determined according to the Devereux formula. Multiple linear regression analysis showed that vitamin D level is independently associated with LVMI (β = -0.259, p = 0.001), aortic distensibility (β = 0.369, p < 0.001), high-sensitive C-reactive protein (hs-CRP) (β = -0.220, p = 0.002) and body mass index (β = -0.167, p = 0.015) in patients with DM. In diabetic patients, serum 25-hydroxyvitamin D level is independently associated with aortic distensibility. Vitamin D may play a role on pathogenesis of impaired elastic properties of aorta in type 2 DM.
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Kuloğlu et al. (2013) conducted a cross-sectional in newly diagnosed type 2 diabetes mellitus (n=136). Serum 25-hydroxyvitamin D level was evaluated on aortic distensibility and left ventricle mass index (LVMI) (β = 0.369 for aortic distensibility; β = -0.259 for LVMI, p=<0.001 for aortic distensibility; 0.001 for LVMI). Serum 25-hydroxyvitamin D level was independently associated with aortic distensibility (β = 0.369, p < 0.001) and left ventricle mass index (β = -0.259, p = 0.001) in newly diagnosed type 2 DM.
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