Key result
Vitamin D supplementation in streptozotocin-induced diabetic rats did not improve aortic stiffness or endothelial function, but prevented the fragmentation of elastic fibers in the aortic media.
Why the study?
Does cholecalciferol improve aortic stiffness and endothelial function in streptozotocin-induced diabetic rats?
Population
30 male Wistar rats (age 4 months) with streptozotocin-induced diabetes
Comparison
Cholecalciferol administered orally by gavage… vs Untreated diabetic rats and untreated…
Design
Preclinical, Randomly assigned to control untreated, diabetic untreated, and…
Follow-up
10 weeks
Authors
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Does not support vitamin D for aortic stiffness in diabetic rats; leaves open whether elastic preservation merits human translation.
Does cholecalciferol improve aortic stiffness and endothelial function in streptozotocin-induced diabetic rats?
Absolute Event Rate: 2.29% vs 1.84%
p-value: p=<0.05
In a rat model of streptozotocin-induced diabetes, vitamin D supplementation preserved aortic elastic fiber integrity but did not improve functional indices of aortic stiffness or endothelial function.
Salum et al. (2012) studied Streptozotocin-induced diabetes (n=30). Cholecalciferol vs. Untreated diabetic rats was evaluated on Elastic fibers in aortic media (arbitrary units) (p=<0.05). Vitamin D supplementation in streptozotocin-induced diabetic rats did not improve aortic stiffness or endothelial function, but prevented the fragmentation of elastic fibers in the aortic media.
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