Key result
Vitamin D attenuates diabetic endothelial dysfunction in rats by reducing oxidative stress and improving NO.
Why the study?
Diabetes mellitus is associated with vascular complications, and vitamin D deficiency is globally widespread, prompting investigation into how diabetes affects endothelial function and the role of vitamin D supplementation.
Does vitamin D supplementation improve endothelial function and reduce oxidative stress in a rat model of diabetes?
Population
30 male Wistar rats
Comparison
Untreated control vs untreated diabetic vs diabetic treated with vitamin D
Design
Randomized animal study
Follow-up
10 weeks
Authors
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Does not support vitamin D use in diabetic patients; leaves open translation of rat endothelial benefits to human trials.
RCT (n=30)
Randomized
Does vitamin D supplementation improve endothelial function and reduce oxidative stress in a rat model of diabetes?
Vitamin D supplementation attenuates endothelial dysfunction and reduces oxidative stress in a rat model of diabetes, suggesting potential utility in preventing diabetic vascular complications.
Mona A. Said (2020) conducted an RCT in Diabetes mellitus (streptozotocin-induced) (n=30). Vitamin D vs. Untreated diabetic and untreated non-diabetic controls was evaluated on Endothelial function and oxidative stress markers (serum glucose, ADMA, aortic MDA, ET-1, iNOS, SOD, NO, cNOS). Vitamin D administration (12.5 μg/kg) attenuated diabetic-induced endothelial dysfunction in rats by reducing oxidative stress markers and improving nitric oxide levels.
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