Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Figures

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  Figure 1. Patient flow diagram of the study

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  Figure 2. Change in serum Vitamin D levels after supplementation with 60,000 IU of cholecalciferol weekly for 8 weeks in patients with type 2 diabetes mellitus and Vitamin D deficiency (n = 70) *Wilcoxon signed rank test was used for statistical analysis. Values beside the boxes represent median (interquartile range). P < 0.05 was considered statistically significant

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  Figure 3. Change in serum malondialdehyde levels after supplementation with 60,000 IU of oral cholecalciferol weekly for 8 weeks in patients with type 2 diabetes mellitus and Vitamin D deficiency (n = 70) *paired t-test was used for statistical analysis. Values inside the bars represent mean ± standard deviation. P < 0.05 was considered statistically significant

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  Figure 4. Change in total antioxidant status after supplementation with 60,000 IU of oral cholecalciferol weekly for 8 weeks in patients with type 2 diabetes mellitus and Vitamin D deficiency (n = 70) *paired t-test was used for statistical analysis. Values inside the bars represent mean ± standard deviation. P < 0.05 was considered statistically significant

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  Figure 5. Change in serum malondialdehyde levels after supplementation with 60,000 IU of cholecalciferol/week for 8 weeks in normotensives (n = 35) and hypertensives (n = 35) with type 2 diabetes mellitus and Vitamin D deficiency. Paired t-test was used for statistical analysis; P < 0.05 was considered statistically significant. *In normotensives, comparing serum malondialdehyde levels before and after treatment, P = 0.001. **In hypertensives, comparing serum malondialdehyde levels before and after treatment, P < 0.001. Values inside bars represent mean ± standard deviation

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  Figure 6. Change in total antioxidant status after supplementation with 60,000 IU of cholecalciferol weekly for 8 weeks in normotensive (n = 35) and hypertensive patients (n = 35) with type 2 diabetes mellitus and Vitamin D deficiency. Paired t-test was used for statistical analysis and P < 0.05 was considered statistically significant. *In normotensives, on comparing total antioxidant status before and after treatment, P < 0.001. **In hypertensive patients, on comparing total antioxidant status before and after treatment, P = 0.002. Values inside the bars represent mean ± standard deviation