Key result
Cryo-electron microscopy of the EV71 A-particle and empty capsid revealed that the icosahedral two-fold axis opens a channel that acts as a gateway regulating viral genome release.
Population
Enterovirus 71 (EV71) strain 1075/Shiga propagated in HeLa cells
Comparison
Heating to 56°C for 12 minutes to produce… vs Native virus/procapsid crystal structures
Design
Preclinical
Authors
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Remains preclinical without clinical implications; extends structural understanding of picornavirus uncoating but leaves therapeutic targeting open.
Cryo-EM structures of EV71 A-particles and empty capsids identify the two-fold channel as the gateway for viral genome release, providing insights into picornavirus uncoating.
Shingler et al. (2013) studied Enterovirus 71. Heat treatment vs. Native virus was evaluated on Cryo-electron microscopy structural reconstruction. Cryo-electron microscopy of the EV71 A-particle and empty capsid revealed that the icosahedral two-fold axis opens a channel that acts as a gateway regulating viral genome release.
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