Key result
Upgrading to cardiac resynchronization therapy in patients with right ventricular pacing-induced cardiomyopathy significantly increased left ventricular ejection fraction from 31.2% to 37.4% (P<0.01).
Why the study?
Does a CRT upgrade improve LV function and symptoms in patients with RV pacing-induced cardiomyopathy?
Population
21 patients with normal baseline LV function who developed right ventricular pacing-induced cardiomyopathy…
Comparison
Upgrade to a cardiac resynchronization therapy… vs Pre-CRT baseline (retrospective self-control)
Design
Cohort
Follow-up
4.9 ± 0.9 months
Authors
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CRT upgrade was associated with LVEF gain in RV pacing cardiomyopathy; leaves open need for randomized confirmation of outcomes.
Cohort (n=21)
Does a CRT upgrade improve LV function and symptoms in patients with RV pacing-induced cardiomyopathy?
Absolute Event Rate: 37.4% vs 31.2%
p-value: p=< 0.01
Upgrading to CRT significantly improves left ventricular ejection fraction and symptoms in patients who develop right ventricular pacing-induced cardiomyopathy.
Nazeri et al. (2009) conducted a cohort in Right ventricular pacing-induced cardiomyopathy (n=21). Cardiac resynchronization therapy (CRT) upgrade vs. Pre-CRT baseline was evaluated on Left ventricular ejection fraction (LVEF) (p=< 0.01). Upgrading to cardiac resynchronization therapy in patients with right ventricular pacing-induced cardiomyopathy significantly increased left ventricular ejection fraction from 31.2% to 37.4% (P<0.01).
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