Relationship Between Insulin Sensitivity and Plasma Leptin Concentration in Lean and Obese Men
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Discussion
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Implication
Randomized trial examines leptin levels and insulin sensitivity in lean and obese men, indicating key metabolic links.
Key Points
- This study assesses the relationship between plasma leptin levels and insulin sensitivity in lean and obese men.
- Three groups studied: lean insulin-sensitive (15±1% body fat), lean insulin-resistant (16±1% body fat), and obese insulin-resistant (31±3% body fat).
- Insulin sensitivity measured by modified intravenous glucose tolerance test and minimal model analysis.
- Adiposity evaluated using hydrodensitometry.
- Leptin levels in lean insulin-sensitive men were significantly lower (1.90±0.4 ng/ml) than in lean insulin-resistant men (4.35±1.21 ng/ml, P<0.05).
- Plasma leptin in obese men (9.27±1.4 ng/ml) was significantly higher than in both lean groups (P<0.01).
- Insulin resistance correlates with higher plasma leptin levels, unaffected by acute changes in insulin concentration.
Cite This Study
Segal et al. (1996) studied this question.