Key result
Active smoking was an independent predictor of higher immature platelet fraction (OR 1.59; 95% CI 1.03-2.45; P=0.035) in patients undergoing coronary angiography.
Why the study?
Mechanisms causing increased platelet aggregability with smoking are incompletely defined, and immature platelets may play a role.
Does active smoking increase immature platelet fraction and is it associated with the extent of coronary artery disease in patients undergoing coronary angiography?
Population
2553 consecutive patients undergoing coronary angiography in a single centre
Comparison
Active smokers vs nonactive smokers
Design
Single-centre observational cohort study
Authors
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May reflect smoking effects on platelet turnover in CAD; leaves open whether immature platelet fraction aids risk stratification.
Cohort (n=2,553)
No
Does active smoking increase immature platelet fraction and is it associated with the extent of coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 1.59 (95% CI 1.03–2.45)
p-value: p=0.035
While active smoking is associated with higher levels of immature platelet fraction, this increase does not correlate with the prevalence or severity of coronary artery disease.
Nardin et al. (2019) conducted a cohort in Patients undergoing coronary angiography (n=2,553). Active smoking vs. Nonactive smokers was evaluated on Higher immature platelet fraction (IPF) (OR 1.59, 95% CI 1.03-2.45, p=0.035). Active smoking was an independent predictor of higher immature platelet fraction (OR 1.59; 95% CI 1.03-2.45; P=0.035) in patients undergoing coronary angiography.
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