Findings of the International Cooperative INTERSALT Study.
Why the study?
Is 24-hour urinary sodium excretion associated with blood pressure in a global population?
Population
10,079 persons from 52 international centers
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports global dietary sodium-potassium hypotheses for BP; leaves causal effects and practice change open for trials.
Structured PICO
Is 24-hour urinary sodium excretion associated with blood pressure in a global population?
P
Population
10,079 persons from 52 international centers
I
Intervention
24-hour urinary sodium excretion, potassium excretion, sodium/potassium ratio, body mass index, and alcohol consumption
O
Outcome
Systolic and diastolic blood pressuresurrogate
The INTERSALT study provides foundational epidemiological evidence linking higher dietary sodium and lower potassium intake to higher blood pressure across diverse global populations.
Cite This Study
Stamler et al. (1991) studied this question.