Key result
In patient-specific computational models of chronic thromboembolic pulmonary hypertension, simulated removal of the proximal obstruction reduced the right-left pressure imbalance by up to 18%.
Why the study?
Can patient-specific computational flow modeling quantify pressure gradients in the pulmonary arteries of CTEPH patients to assist surgical decision-making?
Can patient-specific computational flow modeling quantify pressure gradients in the pulmonary arteries of CTEPH patients to assist surgical decision-making?
Answers are grounded in this paper and cite their sources.
Patient-specific computational modeling can noninvasively quantify hemodynamics in CTEPH, potentially assisting in determining surgical eligibility by differentiating proximal versus distal vascular resistance.
INTRODUCTION: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) results from progressive thrombotic occlusion of the pulmonary arteries. It is treated by surgical removal of the occlusion, with success rates depending on the degree of microvascular remodelling. Surgical eligibility is influenced by the contributions of both the thrombus occlusion and microvasculature remodelling to the overall vascular resistance. Assessing this is challenging due to the high inter-individual variability in arterial morphology and physiology. We investigated the potential of patient-specific computational flow modelling to quantify pressure gradients in the pulmonary arteries of CTEPH patients to assist the decision-making process for surgical eligibility. METHODS: Detailed segmentations of the pulmonary arteries were created from postoperative chest Computed Tomography scans of three CTEPH patients. A focal stenosis was included in the original geometry to compare the pre- and post-surgical haemodynamics. Three-dimensional flow simulations were performed on each morphology to quantify velocity-dependent pressure changes using a finite element solver coupled to terminal 2-element Windkessel models. In addition to transient flow simulations, a parametric modelling approach based on constant flow simulations is also proposed as faster technique to estimate relative pressure drops through the proximal pulmonary vasculature. RESULTS: An asymmetrical flow split between left and right pulmonary arteries was observed in the stenosed models. Removing the proximal obstruction resulted in a reduction of the right-left pressure imbalance of up to 18%. Changes were also observed in the wall shear stresses and flow topology, where vortices developed in the stenosed model while the nonstenosed retained a helical flow. The predicted pressure gradients from constant flow simulations were consistent with the ones measured in the transient flow simulations. CONCLUSION: This study provides a proof of concept that patient-specific computational modelling can be used as a noninvasive tool for assisting surgical decisions in CTEPH based on haemodynamics metrics. Our technique enables determination of the proximal relative pressure, which could subsequently be compared to the total pressure drop to determine the degree of distal and proximal vascular resistance. In the longer term this approach has the potential to form the basis for a more quantitative classification system of CTEPH types.
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Spazzapan et al. (2018) studied Chronic Thromboembolic Pulmonary Hypertension (CTEPH) (n=3). Simulated removal of proximal obstruction vs. Stenosed model (pre-surgical hemodynamics) was evaluated on Right-left pressure imbalance and pressure gradients. In patient-specific computational models of chronic thromboembolic pulmonary hypertension, simulated removal of the proximal obstruction reduced the right-left pressure imbalance by up to 18%.
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