Key result
Left atrial appendage occlusion did not significantly affect the progression of atrial fibrillation in the overall cohort (HR 1.22; 95% CI 0.51-2.91; p=0.657).
Why the study?
Data on the long-term impact of endovascular left atrial appendage isolation on the clinical course of atrial fibrillation were practically absent.
Does LAA occluder implantation affect the progression of atrial fibrillation in patients over 40 years old with paroxysmal or persistent AF?
Cohort (n=102)
Does LAA occluder implantation affect the progression of atrial fibrillation in patients over 40 years old with paroxysmal or persistent AF?
LAA occlusion does not prevent AF progression overall and may increase the risk of progression to permanent AF in patients with baseline paroxysmal AF, though larger studies are needed to confirm this finding.
May support LAA isolation for long-term AF control in selected patients; leaves open need for randomized confirmation before practice change.
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Певзнер et al. (2022) conducted a cohort in Atrial fibrillation (n=102). Left atrial appendage occlusion vs. Anticoagulant therapy alone was evaluated on Progression of atrial fibrillation to permanent or long-standing persistent form (HR 1.22, 95% CI 0.51-2.91, p=0.657). Left atrial appendage occlusion did not significantly affect the progression of atrial fibrillation in the overall cohort (HR 1.22; 95% CI 0.51-2.91; p=0.657).
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