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In cultured chick embryo hepatocytes, induction of cytochrome P450 by nine 5,5‐substituted barbiturates was analyzed for a quantitative structure‐activity relationship. The data led to the following equation: Log 1/C = 1.02 (±0.16) log P + 2.75 (±0.28), r = 0.984 where C is the concentration that caused a 50% increase in cytochrome P450, P is the partition coefficient between octanol and water, and r is the correlation coefficient. The results suggest that the potency of the barbiturates was directly related to their hydrophobicity.
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Hansch et al. (1990) studied this question.
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